Alanylglutamine (Ala-Gln) is a dipeptide used to replace glutamine in mammalian cell culture media.
L-Alanyl-L-Glutamine CAS#39537-23-0
Alanylglutamine (Ala-Gln) is a dipeptide used to replace glutamine in mammalian cell culture media.
This product is a white or off-white crystalline powder, odorless; hygroscopic, easily soluble in water, almost insoluble or intolerant in methanol, and slightly soluble in glacial acetic acid.This product is a component of parenteral nutrition for patients requiring glutamine supplementation, including those in catabolic and hypermetabolic conditions. Examples include: trauma, burns, post-operative medium to large scale surgery, bone marrow and other organ transplants, gastrointestinal syndromes, tumors, severe infections, and other ICU patients in a state of stress. This product is a supplement to amino acid solutions and should be added to other amino acid solutions or infusion solutions containing amino acids when used. It can be used as a substitute for glutamate in mammalian cell culture media and is stable during heat sterilization.
Use: This product is a component of parenteral nutrition for patients requiring glutamine supplementation, including those in catabolic and hypermetabolic conditions. Examples include: trauma, burns, post-operative period after major or medium-sized surgery, bone marrow and other organ transplants, gastrointestinal syndromes, tumors, severe infections, and other ICU patients in a state of stress. This product is a supplement to amino acid solutions and should be added to to other amino acid solutions or infusions containing amino acids at the time of use. A dipeptide for use as a glutamine replacement in mammalian cell culture media; glutamine is unstable in solution and forms ammonia that has deleterious effects in cell culture; Ala-Glu is stable to heat sterilization and forms ammonia with less effect than glutamine. As one of the culture medium components, it is beneficial to utilize its advantages.
Pharmacological effects:This product is a component of parenteral nutrition, N(2)-L-alanyl-L-glutamine can be decomposed into glutamine and alanine in vivo, and its properties can be supplemented by parenteral nutritional infusion of glutamine.The amino acids released from the decomposition of this dipeptide are stored as nutrients in their respective parts of the body and metabolized as needed by the organism. This product can be used for parenteral nutritional support in conditions where glutamine depletion may occur.
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