D-serine is a right-handed amino acid found in neurons, astrocytes, and microglia. Synthesized from L -serine by serine racemase.
D-Serine CAS#312-84-5
D-serine is a right-handed amino acid found in neurons, astrocytes, and microglia. Synthesized from L -serine by serine racemase.
White crystalline powder, irritating to eyes, respiratory tract and skin. Avoid skin and eye contact.
Use I Used as pharmaceutical intermediates, biochemical reagents
Use II Effective in patients with inflammatory diseases such as temporal arteritis and polymyalgia rheumatica.
Use three Used in biochemical research, preparation of tissue culture medium, used as amino acid nutrients in medicine.
Functions:Neurotransmitter effects:NMDA receptor modulation:D-Serine acts as a co-agonist at NMDA receptors and enhances NMDA receptor activity, thereby promoting neurotransmission and synaptic plasticity.NMDA receptors are critical for learning and memory, and thus D-Serine plays an important role in cognitive function. Neuroprotection:Neuroprotective effects:D-Serine has shown potential in several studies to protect nerve cells from damage, especially in situations such as stress, oxidative stress, and inflammation. It may help reduce the symptoms of certain neurodegenerative diseases.
Neurodevelopment:Neurodevelopment:D-Serine is involved in the developmental processes of the nervous system, including nerve cell migration and synapse formation. It plays a supportive role in the development and functional maturation of the brain.
Applications:Mental Disease Treatment:Schizophrenia:D-Serine has been studied as an adjunctive treatment for schizophrenia. Abnormal NMDA receptor function in schizophrenic patients may be associated with symptoms, and D-serine can improve NMDA receptor function to counteract the symptoms of schizophrenia. Depression and Anxiety Disorders:Several studies have suggested that D-serine may have potential benefits in the treatment of depression and anxiety disorders, primarily through improvements in NMDA receptor function and neuroplasticity. Cognitive Enhancement:Cognitive Disorders:D-serine's potential to improve cognitive function is also being explored, particularly in cognitive disorders such as Alzheimer's disease. Researchers are investigating how to enhance memory and learning by adjusting D-serine levels.
Drug Development:New Drug Development: Based on the mechanism of D-serine, pharmaceutical companies are developing novel drugs that may be used to treat psychiatric disorders, neurodegenerative diseases, and other related health problems.
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