Pyridoxal-5-phosphate (PLP) is the active form of vitamin B6, which serves as a coenzyme in a wide range of enzymatic reactions in the body.
Pyridoxal-5-phosphate CAS 54-47-7
Pyridoxal-5-phosphate (PLP) is the active form of vitamin B6, which serves as a coenzyme in a wide range of enzymatic reactions in the body.
Pyridoxal-5-phosphate is a yellow to orange crystalline powder that has a slight characteristic odor. It is the active form of vitamin B6 and plays a crucial role in various enzymatic reactions, including amino acid metabolism, neurotransmitter synthesis, and the production of hemoglobin. This coenzyme is vital for maintaining proper brain function, supporting immune health, and regulating hormonal activity, making it essential for overall health and well-being.
Functions and applications:
1. Amino Acid Metabolism: PLP plays a crucial role in the metabolism of amino acids, serving as a cofactor for enzymes involved in both the synthesis and breakdown of amino acids. It is particularly important in reactions such as transamination, decarboxylation, and racemization, which are essential for the interconversion and utilization of amino acids.
2. Neurotransmitter Synthesis: PLP is involved in the synthesis of several neurotransmitters, including serotonin, dopamine, epinephrine, and gamma-aminobutyric acid (GABA). These neurotransmitters are critical for nerve signaling, mood regulation, and cognitive function.
3. Heme Synthesis: PLP participates in the synthesis of heme, the iron-containing component of hemoglobin in red blood cells. Adequate PLP levels are essential for proper heme synthesis, which is crucial for oxygen transport in the blood.
4. Glycogen Metabolism: PLP is involved in glycogen metabolism, playing a role in glycogen phosphorylase activation and glycogen synthase inhibition. This helps regulate blood glucose levels by facilitating the breakdown of glycogen into glucose when energy demands are high.
5. Immune Function: PLP is important for immune function, as it is involved in the production of antibodies and the proliferation of immune cells. Adequate PLP levels support a healthy immune response against infections and diseases.
6. Gene Expression Regulation: PLP participates in the regulation of gene expression by influencing the activity of certain enzymes involved in DNA synthesis, repair, and methylation.
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