Citronellol is a natural organic compound commonly used as an ingredient in flavors and perfumes, with a fresh floral and citrus aroma.
Citronellol CAS#106-22-9
Citronellol is a natural organic compound commonly used as an ingredient in flavors and perfumes, with a fresh floral and citrus aroma.
Colorless oily liquid; fresh rose-like aroma.Citronellol is a natural plant essential oil ingredient with multiple pharmacological activities. It belongs to the alcohol class and has a relaxing aroma that helps relieve anxiety. In addition, it has the effects of soothing the liver and regulating qi, relieving the stomach, and resolving phlegm. It is used to treat symptoms such as liver and stomach qi stagnation, chest and flank pain, abdominal distension, vomiting, belching, and coughing with phlegm.
In addition, Citronellol has cleansing properties and repellent activity, which helps the skin stay young and healthy.Citronellol is an orally available monoterpenoid compound with multiple biological activities, including cytotoxicity, anti-oxidative stress, regulation of autophagy pathway, and neuroprotection. Specifically, Citronellol is cytotoxic to A549, NCI-H1299, NCI-H23, BT-20, and PC3 cells with IC50 values of 54.02, 40.64, 52.51, 45.84, and 50.1 μg/mL, respectively. In addition, Citronellol can prevent 6-OHDA-induced oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model by regulating ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. It can also induce necroptosis in human lung cancer cells through the TNF-α pathway and reactive oxygen species accumulation.
Citronellol can regulate the autophagy pathway by reducing LC-3 and p62 levels, inhibiting oxidative stress and neuroinflammation, and thus has a neuroprotective effect on Parkinson's rats. In addition, Citronellol can be used in the study of tumors, Parkinson's disease, and cardiovascular diseases. Citronellol, a compound related to Citronellol, also has certain biological activities. It is a monoterpene with sedative, hypnotic and anti-nociceptive properties, which can reduce mechanical nociception, partly mediated by NO-cGMP-ATP-sensitive K+ channels.
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